Montair (Montelukast) vs. Alternatives: Full Comparison Guide 11 October 2025
Thomas Barrett 1 Comments

Montair vs. Alternatives: Quick Comparison Tool

Comparison Details

Quick Summary

Montair is a leukotriene receptor antagonist (LTRA) that blocks inflammatory chemicals in the lungs. It's taken once daily as a tablet, making it easy for children or those struggling with inhalers. Common side effects include headache, stomach upset, and mood changes.
Singulair is the generic version of Montair, offering the same benefits at a lower cost.
Inhaled Corticosteroids like Fluticasone and Budesonide provide strong anti-inflammatory control but require proper inhaler technique. They are typically used for more severe asthma.
Zafirlukast and Zileuton are also LTRAs but come with higher risks such as liver toxicity.
Omalizumab is a biologic therapy reserved for severe allergic asthma that doesn't respond to standard treatments.

When you pick a daily asthma pill, Montair is a brand of montelukast, a leukotriene receptor antagonist that helps keep airways open. It’s popular because you just swallow a tablet once a day, no inhaler tricks needed. But you might wonder if there’s a cheaper brand, a stronger inhaled spray, or a newer biologic that works better for you. This guide lines up Montair side‑by‑side with the most common alternatives, so you can see where each one shines or falls short.

What Montair (Montelukast) Actually Does

Montair contains the active ingredient Montelukast, which blocks leukotrienes - inflammatory chemicals that cause bronchoconstriction and swelling in the lungs. By binding to leukotriene receptors, it reduces asthma attacks and eases allergic rhinitis. It’s taken orally, usually 10mg for adults and 4mg for kids over 6months. Because it works systemically, you don’t need a spacer or timed inhalations, making it a handy option for children or anyone who struggles with inhaler technique.

Key Alternatives on the Market

  • Singulair - another brand of montelukast, often cheaper in bulk.
  • Fluticasone propionate - an inhaled corticosteroid (ICS) delivered via a metered‑dose inhaler.
  • Budesonide - an ICS that comes as a dry‑powder inhaler or nebuliser solution.
  • Zafirlukast - a different leukotriene receptor antagonist (LTRA) taken twice daily.
  • Zileuton - a 5‑lipoxygenase inhibitor that blocks leukotriene production upstream.
  • Omalizumab - an anti‑IgE monoclonal antibody given as a subcutaneous injection every 2‑4 weeks for moderate‑to‑severe allergic asthma.

Side‑Effect Profiles at a Glance

Every drug has trade‑offs. Montair’s most common complaints are mild headache, stomach upset, and occasional mood changes. Singulair shares the same profile because it’s the same molecule. Inhaled steroids like fluticasone and budesonide can cause oral thrush, hoarse voice, and, rarely, bone density loss with long‑term high doses. Zafirlukast may trigger liver enzyme elevations, so doctors often order blood tests. Zileuton is notorious for liver toxicity and requires regular monitoring. Omalizumab’s side effects include injection site reactions and, in rare cases, anaphylaxis - a reason it’s reserved for patients who haven’t responded to other options.

Lineup of various asthma medications: inhalers, tablets, capsules, and a syringe.

Cost Considerations (Australian Perspective)

Price matters, especially if you’re paying out‑of‑pocket. As of October2025, a 30‑day supply of Montair runs about AU$30-$40, depending on pharmacy. Singulair’s generic version can drop to AU$20‑$25. Inhaled steroids vary: a pack of fluticasone inhalers costs roughly AU$45, while budesonide is around AU$38. Zafirlukast tablets are pricier, about AU$55 for a month’s supply, and Zileuton sits near AU$70. Omalizumab is a big ticket - each injection can be AU$800‑$1,000, though Medicare rebates often offset a portion for eligible patients.

When to Choose Montair Over the Rest

  1. Simplicity: If you dislike inhalers or have kids who can’t master the technique, a once‑daily tablet beats an inhaler.
  2. Mild‑to‑moderate asthma: Montair works well for step‑2 or step‑3 maintenance in the Australian asthma guidelines.
  3. Allergic rhinitis combo: It tackles both asthma and hay‑fever, so you don’t need extra antihistamines.
  4. Cost‑effectiveness: The generic version (Singulair) offers a low‑price entry point for most patients.

When Alternatives Might Beat Montair

If you have frequent nighttime attacks, an inhaled corticosteroid often provides stronger anti‑inflammatory control. For patients with liver concerns, avoid Zileuton and Zafirlukast. Those with severe allergic asthma may need biologics like Omalizumab, which can cut exacerbations by up to 50% in clinical trials. Lastly, if you experience mood swings on Montair, switching to an inhaled steroid or a different LTRA can help.

Doctor and patient reviewing asthma treatment options with medication samples and a liver test tube.

Side‑by‑Side Comparison Table

Key attributes of Montair and its main alternatives
Drug Class Mechanism Typical Dose Frequency Common Side Effects Approx. Monthly Cost (AU$) Best For
Montair LTRA Leukotriene receptor blockade 10mg (adult) Once daily Headache, nausea, mood changes 30‑40 Simple oral regimen, mild‑moderate asthma
Singulair (generic) LTRA Leukotriene receptor blockade 10mg (adult) Once daily Same as Montair 20‑25 Cost‑conscious patients
Fluticasone propionate Inhaled corticosteroid Anti‑inflammatory via glucocorticoid receptor 100‑250µg per actuation Twice daily Oral thrush, hoarseness 45 Patients needing stronger airway inflammation control
Budesonide Inhaled corticosteroid Glucocorticoid‑mediated anti‑inflammation 200‑400µg per inhalation Twice daily Thrush, cough, rare adrenal suppression 38 Patients preferring dry‑powder inhaler
Zafirlukast LTRA Leukotriene receptor blockade 20mg Twice daily Liver enzyme elevation, headache 55 Patients intolerant to montelukast but still need LTRA
Zileuton 5‑Lipoxygenase inhibitor Blocks leukotriene synthesis 600mg Four times daily Liver toxicity, nausea 70 Severe leukotriene‑driven asthma when LTRAs fail
Omalizumab Anti‑IgE biologic Neutralises circulating IgE 150‑600mg (dose based on weight/IgE) Every 2‑4 weeks (subcutaneous) Injection site reaction, rare anaphylaxis 800‑1,000 Moderate‑to‑severe allergic asthma uncontrolled by meds

Quick Decision Checklist

  • Do you struggle with inhaler technique? → Choose Montair or Singulair.
  • Is cost your biggest barrier? → Generic Singulair or budesonide inhaler.
  • Do you have frequent nighttime symptoms? → Switch to an inhaled corticosteroid.
  • Any liver issues? → Avoid Zafirlukast and Zileuton.
  • Severe allergic asthma despite meds? → Talk to your doctor about Omalizumab.

How to Switch Safely

  1. Talk to your GP or respiratory specialist - they’ll assess control level and any comorbidities.
  2. Get a clear taper plan if moving from inhaled steroids to Montair; abrupt stops can cause rebound inflammation.
  3. Schedule liver function tests if starting Zafirlukast or Zileuton.
  4. Monitor symptoms for 2-4 weeks after any change; keep a diary of peak flow, night awakenings, and side‑effects.
  5. Update your Medicare or private health plan about any new injectable therapy like Omalizumab to secure rebates.

Frequently Asked Questions

Can I take Montair and an inhaled steroid together?

Yes, many doctors prescribe Montair as add‑on therapy to an inhaled corticosteroid when asthma control is still sub‑optimal. The combo can lower the dose of steroids needed, reducing side‑effects.

Is Montair safe for children?

Montair is approved for children as young as 6months (4mg dose). It’s often the first‑line oral option because it avoids the coordination required for inhalers.

Why might I feel moody on Montair?

A small but real subset of patients report agitation, anxiety, or depression on montelukast. If mood changes are noticeable, discuss switching to an inhaled steroid or another LTRA with your doctor.

How does Omalizumab differ from Montair?

Omalizumab targets the root cause - IgE antibodies - and is given by injection every few weeks. Montair works downstream by blocking leukotrienes. Omalizumab is reserved for severe allergic asthma that doesn’t improve with pills or inhalers.

Do I need liver tests for Zileuton?

Yes. Baseline liver enzymes are checked before starting, then every month for the first three months, and periodically thereafter. This monitoring is crucial because Zileuton can cause serious hepatic injury.

1 Comments

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    Carlise Pretorius

    October 11, 2025 AT 13:22

    Montair is real nice option for kids who cant use inhalers

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